UG Lactacystin; Synthetic 1PC X 400UG

Code: 426100-400UG D2-231

Biochem/physiol Actions

Primary Target20S proteasome (MCP; multicatalytic proteinase complex)

Cell permeable: no

Reversible: no

Target IC50: 500 ...


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Your Price
€561.08 EACH
€690.13 inc. VAT

Biochem/physiol Actions

Primary Target20S proteasome (MCP; multicatalytic proteinase complex)

Cell permeable: no

Reversible: no

Target IC50: 500 nM against 20S proteasome; 10 µM against NF-κB activation

Product does not compete with ATP.

General description

An irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells beyond theG1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 µM)

An irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin- and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells and inhibits progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol.27, 123.Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem.31, 279.Dick, L.R., et al. 1996. J. Biol. Chem.271, 7273.Oda, K., et al. 1996. Biochem. Biophys. Res.Commun.219, 800.Fenteany, G., et al. 1995. Science268, 726.Imajoh-Ohmi, S., et al. 1995. Biochem.Biophys. Res. Commun.217, 1070.Jensen, T.J., et al. 1995. Cell 83, 129.Katagiri, M.M., et al. 1995. J. Antibiot.48, 344.Mori, S., et al. 1995. J. Biol. Chem.270, 29447.Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun.216, 291.Fenteany, G., et al. 1994. Proc. Natl. Acad.Sci. USA91, 3358.Omura, S., et al. 1991. J. Antibiot.44, 117.

Packaging

1 mg in Glass bottle

200, 400 µg in Plastic ampoule

Reconstitution

Following reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Unstable in aqueous solutions; reconstitute in H2O just prior to use.

Warning

Toxicity: Standard Handling (A)

assay≥99% (HPLC)
colorwhite
formsolid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilityDMSO: 50 mg/mL, water: soluble
storage conditionOK to freeze
storage temp.−20°C
Cas Number1258004-00-0
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